Poxvirus vectors: orphaned and underappreciated.
نویسندگان
چکیده
منابع مشابه
The canarypox virus vector ALVAC induces distinct cytokine responses compared to the vaccinia virus-based vectors MVA and NYVAC in rhesus monkeys.
Despite the growing use of poxvirus vectors as vaccine candidates for multiple pathogens and cancers, their innate stimulatory properties remain poorly characterized. Here we show that the canarypox virus-based vector ALVAC induced distinct systemic proinflammatory and antiviral cytokine and chemokine levels following the vaccination of rhesus monkeys compared to the vaccinia virus-based vector...
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متن کاملA poxvirus-derived vector that directs high levels of expression of cloned genes in mammalian cells.
High levels of expression of cloned genes have been obtained in mammalian cells by using poxvirus-derived insertion/expression vectors. These vectors employ the cis-acting element (CAE I) that directs the transcription of one of the most strongly expressed genes of cowpox virus. This gene (the 160K gene) encodes the 160-kDa protein that is the major component of the A-type cytoplasmic inclusion...
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عنوان ژورنال:
- The Journal of clinical investigation
دوره 105 8 شماره
صفحات -
تاریخ انتشار 2000